IDEXX Kidney Health
IDEXX kidney health solutions
The tools you need to assess kidney function, injury, and management of treatment—resulting in better outcomes throughout the life of your patients.
IDEXX SDMA testing
Whether in-house or at the reference lab, SDMA can keep you ahead of the curve when it comes to declining kidney function—detecting mild to moderate loss that creatinine misses.1–3
Including SDMA in your chemistry profile adds substantial value for both the sick and well patient in the early detection of primary renal diseases as well as the reflection of impact on renal health caused by concurrent diseases.2–14
Undetectable kidney injury is now detectable.
IDEXX Cystatin B Test
With the IDEXX Cystatin B Test, IDEXX’s kidney health suite is more comprehensive than ever. Never before have veterinarians been able to detect active or acute injury to the kidneys. Now with the IDEXX Cystatin B Test, a simple urine-based test, you can uncover kidney injury when clinical signs may or may not be apparent and gain additional insights beyond the changes in functional markers such as SDMA and creatinine.
Learn about the IDEXX Cystatin B Test
Stay ahead of phosphorus overload.
IDEXX FGF-23 Test
The IDEXX FGF-23 Test is an entirely new method to manage and monitor phosphorus overload in cats with chronic kidney disease (CKD) and is now included in the IRIS Treatment Recommendations for CKD in Cats.15
The IDEXX FGF-23 Test can enable confident treatment recommendations, such as diet changes, and it can offer early detection of metabolic bone disease in cats with IRIS CKD Stages 1 and 2.16,17
Learn about the IDEXX FGF-23 Test
Round out your view.
Complete urinalysis and UPC
A complete urinalysis and urine protein:creatinine (UPC) ratio contribute to a deeper view of kidney health. Looking at urine specific gravity (USG) also provides needed context regarding hydration status as well as kidney function when interpreted alongside the functional kidney biomarkers. In addition, including a UPC ratio may aid in the diagnosis and treatment of CKD. Complete urine testing is integral to confidently assess your patients' kidney health status
SediVue Dx Urine Sediment Analyser
Catalyst One Chemistry Analyser
References
1. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683. doi:10.1111/jvim.12445
2. Nabity MB, Lees GE, Boggess MM, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044. doi:10.1111/jvim.12835
3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802. doi:10.1111/jvim.13942
4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596. doi:10.1016/j.tvjl.2014.10.021
5. Nabity MB. Traditional renal biomarkers and new approaches to diagnostics. Toxicol Pathol. 2018;46(8):999–1001. doi:10.1177/0192623318800709
6. Hall JA, Yerramilli M, Obare E, Li J, Yerramilli M, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in cats with kidney stones. PLoS One. 2017;12(4):e0174854. doi:10.1371/journal.pone.0174854
7. Burton W, Drake C, Ogeer J, et al. Association between exposure to Ehrlichia spp. and risk of developing chronic kidney disease in dogs. J Am Anim Hosp Assoc. 2020;56(3):159–164. doi:10.5326/JAAHA-MS-7012
8. Dahlem DP, Neiger R, Schweighauser A, et al. Plasma symmetric dimethylarginine concentration in dogs with acute kidney injury and chronic kidney disease. J Vet Intern Med. 2017;31(3):799–804. doi:10.1111/jvim.14694
9. Drake C, Coyne M, McCrann DJ, Buch J, Mack R. Risk of development of chronic kidney disease after exposure to Borrelia burgdorferi and Anaplasma spp. Top Companion Anim Med. 2021;42:100491. doi:10.1016/j.tcam.2020.100491
10. Szlosek D, Robertson J, Quimby J, et al. A retrospective evaluation of the relationship between symmetric dimethylarginine, creatinine and body weight in hyperthyroid cats. PLoS One. 2020;15(1):e0227964. doi:10.1371/journal.pone.0227964
11. Yerramilli M, Farace G, Quinn J, Yerramilli M. Kidney disease and the nexus of chronic kidney disease and acute kidney injury: the role of novel biomarkers as early and accurate diagnostics. Vet Clin North Am Small Anim Pract. 2016;46(6):961–993. doi:10.1016/j.cvsm.2016.06.011
12. Mack RM, Hegarty E, McCrann DJ, Michael HT, Grauer GF. Longitudinal evaluation of symmetric dimethylarginine and concordance of kidney biomarkers in cats and dogs. Vet J. 2021;276:105732. doi:10.1016/j.tvjl.2021.105732
13. Michael HT, Mack RM, Hegarty E, McCrann DJ, Grauer GF. A longitudinal study of the persistence of increased creatinine and concordance between kidney biomarkers in cats and dogs. Vet J. 2021;276:105729. doi:10.1016/j.tvjl.2021.105729
14. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.
15. International Renal Interest Society. Announcement of changes to IRIS guidelines. Accessed February 8, 2023. www.iris-kidney.com/guidelines/guidelines_updates_2023.html
16. Geddes RF, Elliott J, Syme HM. The effect of feeding a renal diet on plasma fibroblast growth factor 23 concentrations in cats with stable azotemic chronic kidney disease. J Vet Intern Med. 2013;27(6):1354–1361. doi:10.1111/jvim.12187
17. Geddes RF, Biourge V, Chang Y, Syme HM, Elliott J. The effect of moderate dietary protein and phosphate restriction on calcium-phosphate homeostasis in healthy older cats. J Vet Intern Med. 2016;30(5):1690–1702. doi:10.1111/jvim.14563
18. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA. Individual results will vary based upon each patient’s case complexity and practitioner’s IRIS CKD staging experience. www.idexx.com/en/veterinary/reference-laboratories/sdma/sdma-iris/#vetconnectplus